Interactions Clorazepate





all sedatives or hypnotics e.g. other benzodiazepines, antiepileptic drugs, alcohol, antihistamines, opiates, neuroleptics, sleep aids magnify effects of clorazepate on central nervous system. drugs may interact clorazepate include, digoxin, disulfiram, fluoxetine, isoniazid, ketoconazole, levodopa, metoprolol, hormonal contraceptives, probenecid, propranolol, rifampin, theophylline, valproic acid. selective serotonin reuptake inhibitors, cimetidine, macrolide antibiotics , antimycotics inhibit metabolism of benzodiazepines , may result in increased plasma levels resultant enhancement of adverse effects. phenytoin, phenobarbital, , carbamazepine have opposite effect, coadministration leading increased metabolism , decreased therapeutic effects of clorazepate.








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