Adverse effects Clorazepate

delirium has been noted discontinuation clorazepate

a benzodiazepine dependence occurs in approximately 1 third of patients take benzodiazepines longer 4 weeks, characterised withdrawal syndrome upon dose reduction. when used seizure control, tolerance may manifest increased rate of seizures increased risk of withdrawal seizures. in humans, tolerance anticonvulsant effects of clorazepate occurs regular use. due development of tolerance, benzodiazepines are, in general, not considered appropriate long-term management of epilepsy; increasing dose may result in developing of tolerance higher dose combined worsened adverse effects. cross-tolerance occurs between benzodiazepines, meaning that, if individuals tolerant 1 benzodiazepine, display tolerance equivalent doses of other benzodiazepines. withdrawal symptoms benzodiazepines include worsening of pre-existing symptoms appearance of new symptoms not pre-existing. withdrawal symptoms may range mild anxiety , insomnia severe withdrawal symptoms such seizures , psychosis. withdrawal symptoms can difficult in cases differentiate between pre-existing symptoms , withdrawal symptoms. use of high doses, long-term use , abrupt or over-rapid withdrawal increases increase severity of withdrawal syndrome. however, tolerance active metabolite of clorazepate may occur more other benzodiazepines. regular use of benzodiazepines causes development of dependence characterised tolerance therapeutic effects of benzodiazepines , development of benzodiazepine withdrawal syndrome including symptoms such anxiety, apprehension, tremor, insomnia, nausea, , vomiting upon cessation of benzodiazepine use. withdrawal benzodiazepines should gradual abrupt withdrawal high doses of benzodiazepines may cause confusion, toxic psychosis, convulsions, or condition resembling delirium tremens. abrupt withdrawal lower doses may cause depression, nervousness, rebound insomnia, irritability, sweating, , diarrhea.